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In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats

✍ Scribed by Stephan W. Barth; Karlis Briviba; Bernhard Watzl; Nicole Jäger; Doris Marko; Melanie Esselen


Book ID
112012050
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
386 KB
Volume
5
Category
Article
ISSN
1860-6768

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Camptothecin-1 1 (CPT-11) is a new derivative of camptothecin, a plant alkaloid antitumor agent. Previous studies indicated that antitumor activity of CPT-11 was mediated through interaction of the drugs with its target enzyme, DNA topoisomerase I (topo I). In this study, we studied the relation bet