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In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

✍ Scribed by Karen Dell Brown Smith; Verena Kallhoff; Hui Zheng; Robia G. Pautler


Book ID
118490508
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
417 KB
Volume
35
Category
Article
ISSN
1053-8119

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## Abstract ## Purpose To demonstrate an MRI method for directly visualizing amyloid‐β (AΞ²) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T~1ρ~ relaxation rate increases progressively with Alzheimer's disease (AD)‐related pathology in the tg mouse brain. ## Materials a