In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-d-aspartate receptor blockers

✍ Scribed by Motoomi Nakamura; Shimako Abe; Yoshinobu Goto; Akiko Chishaki; Kouhei Akazawa; Motohiro Kato

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 799 KB
• Volume: 17
• Category: Article
• ISSN: 0920-1211
• DOI: 10.1016/0920-1211(94)90055-8

✦ Synopsis

The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex. In the present study, we examined the roles of N-methyl-D-aspartate (NMDA) receptors in this seizure model. The intraperitoneal administration of the competitive NMDA receptor blocker DL-2-amino-7-phosphonoheptanoic acid (36 and 72 mg/kg) and the non-competitive NMDA receptor blocker MK-801 (1.35 and 2.7 mg/kg), completely prevented the induction of seizure and bradyarrhythmia or sudden death resulting from seizure. Therefore, the white-noise-induced seizures in Mg-deficient rats are linked to increased neuronal excitability via the NMDA receptor.