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In vivo antagonism of agonist actions at N-methyl-d-aspartate and N-methyl-d-aspartate-associated glycine receptors in mouse cerebellum: Studies of 1-hydroxy-3-aminopyrrolidone-2

✍ Scribed by P.L. Wood; M.R. Emmett; T.S. Rao; S. Mick; Julie Cler; E. Oei; S. Iyengar


Book ID
118956240
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
516 KB
Volume
29
Category
Article
ISSN
0028-3908

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## Abstract Serine racemase (SR) is responsible for the biosynthesis of D‐serine (D‐Ser), an endogenous co‐agonist for the glycine (Gly)‐binding site on __N__‐methyl‐D‐aspartate (NMDA) receptors, from L‐Ser in the brain. We have previously demonstrated high expression of SR by chondrocytes in carti