Inducing apoptosis of activated lymphocytes via Fas ligand (FasL, CD95) may be a useful strategy for the treatment of autoimmune diseases mediated by pathogenic T cells. We propose that B cells may be ideal tools for effective delivery of a FasL-mediated apoptotic signal to pathogenic T cells for a
In vivo Antagonism of a T Cell Response by an Endogenously Expressed Ligand
โ Scribed by Devraj Basu, Calvin B. Williams and Paul M. Allen
- Book ID
- 123641676
- Publisher
- National Academy of Sciences
- Year
- 1998
- Tongue
- English
- Weight
- 842 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/46536
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Altered peptide ligands derived from Tโcellโreactive self antigens have been shown to be protective therapeutic agents in animal models of autoimmunity. In this study we identified several altered peptide ligands derived from the typeโ1 diabetesโassociated autoantigen human glutamic aci
To determine whether altered peptide ligands (APL) affect calcium signaling events, we investigated changes in intracellular calcium concentration ([Ca 2+ ] i ) in human T cell clone stimulated with either the fully agonistic peptide M12p54-68, the partially agonistic analogue E63V or the simple ant