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In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse

✍ Scribed by Paterson, Hugh F.

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 746 KB
Volume: 211
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402110214

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✦ Synopsis

Abstract

An histological study reveals that embryos homozygous for the mutation tail‐short (Ts) become abnormal as morulae, although a small amount of cell division may continue to take place during the following day. Homozygotes can be identified at 3½ days post coitum (p.c.) by several criteria including low cell number, absence of cavitation, and weak cytoplasmic staining with haematoxylin. A similar pattern of developmental arrest is exhibited during culture, although an initial degreeof cavitation occurs more frequently.

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