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In vivo and in vitro recovery of defective friend virus by various leukemia viruses

✍ Scribed by A. Howard Fieldsteel; Peter J. Dawson; Carole Kurahara

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
450 KB
Volume
8
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Friend virus‐induced reticulum cell sarcomas afler growth in tissue culture were shown to be free from infectious virus. Retrieval of infectious Friend virus could be accomplished with the aid of Moloney leukemia virus, Graffi leukemia virus, and the lymphatic leukemia virus associated with Friend virus, using both in vivo and in vitro techniques. On initial isolation, the pseudotypes differed from original Friend virus in their markedly reduced ability to induce Friend disease in other than newborn BALB/c mice. It was concluded that, although Friend virus may also exist in a non‐defective form, there was no evidence that the tumors contained other than helper‐dependent virus.

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