## Abstract Connexins have long been believed to suppress tumour development during carcinogenesis by exerting gap junctional intercellular communication (GJIC). Although GJIC is abrogated in hepatocellular carcinoma (HCC), connexin32 (Cx32) protein tends to remain expressed in cytoplasm, but not i
β¦ LIBER β¦
In vivo and in vitro phosphorylation of rice dwarf phytoreovirus Pns12 cytoplasmic nonstructural protein
β Scribed by N. Suzuki; D. Hosokawa; Y. Matsuura; A. Kikuchi; T. Omura
- Publisher
- Springer Vienna
- Year
- 1999
- Tongue
- English
- Weight
- 245 KB
- Volume
- 144
- Category
- Article
- ISSN
- 1432-8798
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The NS5A replication complex inhibitor, BMS-790052, inhibits hepatitis C virus (HCV) replication with picomolar potency in preclinical assays. This potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a 14-day multiple-ascending dose (MAD) monotherapy stu