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In vivo and in vitro experimental axotomy mimics a subtype of dystrophic neurite associated with beta-amyloid plaque formation in Alzheimer's disease

✍ Scribed by James C. Vickers; Paul A. Adlard; Tracey C. Dickson; Carolyn E. King


Book ID
117411774
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
174 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract Transgenic mice overexpressing the London mutant of human amyloid precursor protein (APP[V717I]) in neurons develop amyloid plaques in the brain, thus demonstrating the most prominent neuropathological hallmark of Alzheimer's disease. In vivo 3D __T__~2~\*‐weighted MRI on these mice (24