In vivo and in vitro changes in renal function caused by ochratoxin a in the rat
β Scribed by W.O. Berndt; A.W. Hayes
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 585 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0300-483X
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The mycotoxin ochratoxin A (OA) consists of 5-chloro-3-methyl-3,4-dihydro-8-hydroxyisocoumarin moiety linked by an amide bond to p-Lphenylalanine. When added to washed rat platelets in vitro, OA caused a dose-dependent inhibition of aggregation induced by agonists such as adenosine diphosphate (ADP)
## Abstract The mycotoxin ochratoxin A is a contaminant of human and animal food products. It is a potent nephrotoxin known to damage the proximal tubule. The aim of this work was to investigate the effects of ochratoxin A on a porcine renal proximal tubular epithelial cell line (LLCβPK1), and to i
Ochratoxin A (OTA), a nephrotoxic and carcinogenic mycotoxin, has been implicated as an etiologic agent in the Balkan endemic nephropathy (BEN), a chronic disease affecting populations in the Balkans. Compared with unaffected individuals, patients suffering from BEN and/or urinary tract tumors were