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In vivo and enzymatic conversion of toyocamycin to sangivamycin by Streptomyces rimosus

โœ Scribed by Takayoshi Uematsu; Robert J. Suhadolnik


Book ID
115702169
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
521 KB
Volume
162
Category
Article
ISSN
0003-9861

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An enzymatic method for removing embryo-toxic ammonium from culture medium has been developed. Ammonium, produced by both embryo metabolism and spontaneous breakdown of amino acids at 37"C, is transaminated by glutamate dehydrogenase to nontoxic glutamate. Initially, the individual components of the