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In vivo analysis of mammary and non-mammary tumorigenesis in MMTV-cyclin D1 transgenic mice deficient in p53

✍ Scribed by Yoshitaka Hosokawa; Alexandros Papanikolaou; Robert D. Cardiff; Katsuhiko Yoshimoto; Megan Bernstein; Timothy C. Wang; Emmett V. Schmidt; Andrew Arnold


Book ID
110308917
Publisher
Springer Netherlands
Year
2001
Tongue
English
Weight
101 KB
Volume
10
Category
Article
ISSN
0962-8819

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A prominent phenotype of plasmin deficiency in mice is reduced metastasis in the MMTV-PymT transgenic breast cancer model. Proteolytically active plasmin is generated from inactive plasminogen by one of 2 activators, uPA or tPA. We now find that uPA deficiency alone significantly reduces metastasis