In vivo amyloid plaque detection using contrast-enhanced magnetic resonance microscopy in transgenic mice
β Scribed by Alexandra Petiet; Anne Bertrand; Christopher Wiggins; Diane Houitte; Thomas Debeir; Thomas Rooney; Marc Dhenain
- Book ID
- 118464742
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 345 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1552-5260
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract One of the cardinal pathologic features of Alzheimer's disease (AD) is the formation of senile, or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop βhumanβlikeβ plaques, prov
## Abstract The presence of amyloidβΞ² (AΞ²) plaques in the brain is a hallmark pathological feature of Alzheimer's disease (AD). Transgenic mice overexpressing mutant amyloid precursor protein (APP), or both mutant APP and presenilinβ1 (APP/PS1), develop AΞ² plaques similar to those in AD patients, a