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In vivo administration of the 5-HT1A receptor agonist 8-OH-DPAT interferes with brain GABAA/ benzodiazepine receptor complexes

✍ Scribed by B. Söderpalm; G. Andersson; C. Enerbäck; J.A. Engel

Book ID
117187967
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
865 KB
Volume
36
Category
Article
ISSN
0028-3908

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Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei
✍ Deborah S. Kreiss; Irwin Lucki 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB 👁 1 views

The present study investigated alterations of the regulation of serotonin (5-hydroxytryptamine; 5-HT) release by 5-HT 1A autoreceptors following single and repeated treatment with the 5-HT 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Rats were pretreated with 8-OH-DPAT (1.