In vivo 3T spiral imaging based multi-slice T1ρ mapping of knee cartilage in osteoarthritis
✍ Scribed by Xiaojuan Li; Eric T. Han; C. Benjamin Ma; Thomas M. Link; David C. Newitt; Sharmila Majumdar
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 385 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
T~1ρ~ describes the spin‐lattice relaxation in the rotating frame and has been proposed for detecting damage to the cartilage collagen‐proteoglycan matrix in osteoarthritis. In this study, a multi‐slice T~1ρ~ imaging method for knee cartilage was developed using spin‐lock techniques and a spiral imaging sequence. The adverse effect of T~1~ regrowth during the multi‐slice acquisition was eliminated by RF cycling. Agarose phantoms with different concentrations, 10 healthy volunteers, and 9 osteoarthritis patients were scanned at 3T. T~1ρ~ values decreased as agarose concentration increased. T~1ρ~ values obtained with imaging methods were compared with those obtained with spectroscopic methods. T~1ρ~ values obtained during multi‐slice acquisition were validated with those obtained in a single slice acquisition. Reproducibility was assessed using the average coefficient of variation of median T~1ρ~, which was 0.68% in phantoms and 4.8% in healthy volunteers. There was a significant difference (P = 0.002) in the average T~1ρ~ within patellar and femoral cartilage between controls (45.04 ± 2.59 ms) and osteoarthritis patients (53.06 ± 4.60 ms). A significant correlation was found between T~1ρ~ and T~2~; however, the difference of T~2~ was not significant between controls and osteoarthritis patients. The results suggest that T~1ρ~ relaxation times may be a promising clinical tool for osteoarthritis detection and treatment monitoring. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.