In-vitro/In-vivocomparison of leuprolide acetate release from an in-situ forming plga system
โ Scribed by Mashayekhi, Roya; Mobedi, Hamid; Najafi, Jamal; Enayati, Marjan
- Book ID
- 121630051
- Publisher
- Springer (Biomed Central Ltd.)
- Year
- 2013
- Tongue
- English
- Weight
- 514 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1560-8115
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The objective of this study was to develop sustained-release sucrose acetate isobutyrate (SAIB) in situ formulations of risperidone for parenteral delivery. The formulations contained SAIB, solvent (anhydrous ethanol, ethyl lactate, or N-methyl-2-pyrrolidone), and additives such as polylactic acid (
The objective of these studies was to develop a leuprolide acetate depot based on an in situ forming drug delivery system (Atrigel(R)) to suppress the pituitary-gonadal axis and in turn the serum testosterone to chemical castration levels for a period of at least 3 months. Formulations with biodegra