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In vitro–in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

✍ Scribed by Eva M. del Amo; Aki T. Heikkinen; Jukka Mönkkönen

Book ID
113592127
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
364 KB
Volume
36
Category
Article
ISSN
0928-0987

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The intestinal efflux pump, P-glycoprotein (P-gp), located in the apical membranes of intestinal absorptive cells, can reduce the bioavailability of a wide range of drugs which are substrates for this membrane transporter. In addition to anticancer and anti-HIV drugs, NCEs for other disease indicati