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In vitroAnti-tumor Activity of Anti-c-erbB-2 × Anti-CD3ɛ Bifunctional Monoclonal Antibody

✍ Scribed by Sugiyama, Yoshihiro ;Aihara, Miki ;Shibamori, Masafumi ;Deguchi, Kyohei ;Imagawa, Kenichi ;Kikuchi, Mikio ;Momota, Hiroshi ;Azuma, Takachika ;Okada, Hidechika ;Alper, Özge ;Hitomi, Jiro ;Yamaguchi, Ken

Book ID
108579444
Publisher
Wiley (Blackwell Publishing)
Year
1992
Tongue
English
Weight
283 KB
Volume
83
Category
Article
ISSN
0910-5050

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## Abstract In the present study, we investigated the mechanisms by which anti‐endoglin (EDG; CD105) monoclonal antibodies (mAbs) suppress angiogenesis and tumor growth. Antihuman EDG mAb SN6j specifically bound to murine endothelial cells and was internalized into the cells __in vitro__. SN6j effe