Design and synthesis of substituted N-(1
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Mu-Fa Zou; Jianjing Cao; Alice L. Rodriguez; P. Jeffrey Conn; Amy Hauck Newman
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Article
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2011
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Elsevier Science
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English
⚖ 510 KB
Based on SAR in the alkyne class of mGlu5 receptor negative allosteric modulators and a set of amidebased positive allosteric modulators, optimized substitution of the aryl 'b' ring was used to create substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides. Results from an mGlu5 receptor functional a