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In vitro transformation by Epstein-Barr virus induces a switch in growth factor and anti-IgM responsiveness in a human leukemic B cell clone

โœ Scribed by Ottmar Janssen; Steven Gillis; Dieter Kabelitz


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
751 KB
Volume
20
Category
Article
ISSN
0014-2980

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Human lymphocytes that produce anti-pneumococcal antibodies were separated and immortalized by Epstein-Barr virus and then cloned. One clone (NAD-Sel) produces an IgA, kappa antibody which is specific for the polysaccharides of type 8 pneumococcus, while not reactive with any of the polysaccharides