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In vitro synthesis of metabolites of14C-pyridostigmine

โœ Scribed by P. A. Burdfield; T. N. Calvey

Book ID
112653929
Publisher
Springer
Year
1974
Tongue
English
Weight
123 KB
Volume
30
Category
Article
ISSN
1420-682X

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## Abstract For studies of pharmacokinetics and drug metabolism of the new orally active, selective phosphodiesterase type V (PDE V) inhibitor vardenafil (Levitra^ยฎ^), the ^14^Cโ€labelled version was synthesised. Starting from the cyanation of 2โ€iodophenol with K^14^CN, an 8โ€step synthesis led to tw