✦ LIBER ✦

In vitro study of the intrinsic toxicity of synthetic surfaces to cells

✍ Scribed by Ertel, Sylvie I. ;Ratner, Buddy D. ;Kaul, Amarjeev ;Schway, Michael B. ;Horbett, Thomas A.

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 818 KB
Volume: 28
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820280603

No coin nor oath required. For personal study only.

✦ Synopsis

A trypan blue inclusion assay was used to mea-were consistently found to induce cell death. This sure cell death on poly(dimethy1 siloxane) (PDMS), toxic effect disappeared if the cells were seeded in polyethylene (PE), poly(methy1 methacrylate) (PMMA), serum-containing medium or if concentrated solutions of polyurethanes, glass, and glow-discharge-treated poly-proteins (albumin, IgG, or fibronectin) were preadsorbed styrene or poly(ethy1ene terephthalate). Cell lines used on the materials. The substrate toxicity appeared to be were bovine aortic endothelial, 3T3, mouse peritoneal due to the physical properties of the substrate and not to macrophage, and BHK cells. In the absence of proteins in the release of toxic leachables.

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