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In vitro studies on drug interaction of ifosfamide and ACNU in primary and metastatic human brain tumours

✍ Scribed by Ulrich Bogdahn; Daniela Drenkard; Maximilian Lutz; Rainer Apfel; Christian Behl


Book ID
112574260
Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
749 KB
Volume
117
Category
Article
ISSN
1432-1335

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## Abstract ## Background The neurotropic herpes simplex virus mutant HSV1716 lacks the gene encoding the virulence factor ICP34.5 and cannot replicate in non‐dividing cells where proliferating cell nuclear antigen (PCNA) is not actively engaged in cellular DNA synthesis. In the brain, tumoral exp