In vitro studies on cell-mediated immunity following surgery in mice sensitized to syngeneic mammary tumors
✍ Scribed by G. H. Heppner
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- French
- Weight
- 493 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The effect of surgical removal of a tumor on cellular immunity, and on serumblocking activity of cellular immunity, was studied in mice sensitized by transplantation to syngeneic mammary tumors. Immunity was assayed in vitro by colony inhibition tests. Cell‐mediated immunity, tested 10‐15 days after surgery, was enhanced in mice from which tumors had either been completely excised, or left intact after sham surgery, as compared to mice which had experienced no surgical treatment. Blocking activity was depressed by complete removal of the tumor, but not by sham surgery alone. In mice which had complete removal, blocking activity decreased with time following surgery, being lower 10‐15 days than 1‐5 days after treatment.