𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists

✍ Scribed by Perner, Richard J.; DiDomenico, Stanley; Koenig, John R.; Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Drizin, Irene; Zheng, Guo Zhu; Turner, Sean C.; Jinkerson, Tammie; Brown, Brian S.; Keddy, Ryan G.; Lukin, Kurill; McDonald, Heath A.; Honore, Prisca; Mikusa, Joe; Marsh, Kennan C.; Wetter, Jill M.; St. George, Karen; Jarvis, Michael F.; Faltynek, Connie R.; Lee, Chih-Hung


Book ID
120373152
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
164 KB
Volume
50
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Structure–activity relationships and in
✍ Paul J. Beswick; Andy Billinton; Laura J. Chambers; David K. Dean; Elena Fonfria 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 381 KB

Structure-activity relationships (SAR) of analogues of lead compound 1 were investigated and compound 16 was selected for further study in animal models of pain. Compound 16 was shown to be a potent antihyperalgesic agent in both the rat acute complete Freund's adjuvant (CFA) model of inflammatory p