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In vitro sensitivity of human HaCat keratinocytes to topoisomerase inhibitors

✍ Scribed by Pessina, A.; Piccirillo, M.; Raimoddi, A.; Berti, E.; Cerri, A.


Book ID
119562109
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
159 KB
Volume
16
Category
Article
ISSN
0923-1811

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Topoisomerase inhibitor camptothecin sen
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Topoisomerases are nuclear enzymes that maintain and modulate DNA structure. Inhibitors of topoisomerases like camptothecin (CPT), etoposide, and others are widely used antitumor drugs that interfere with transcription, induce DNA strand breaks, and trigger apoptosis preferentially in dividing cells