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In vitro protein binding of propafenone and 5-hydroxypropafenone in serum, in solutions of isolated serum proteins, and to red blood cells

✍ Scribed by George R. Tonn; Charles R. Kerr; James E. Axelson

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
774 KB
Volume
81
Category
Article
ISSN
0022-3549

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Binding of triethylenethiophosphoramide (thio-TEPA) in serum from healthy individuals and from cancer patients and its binding to isolated serum protein fractions were studied by equilibrium dialysis. A drug-protein binding in the order of 10% was demonstrated in serum, with little interindividual v