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In vitro Production of 1,25-dihydroxyvitamin D$_{3}$ by Rat Placental Tissue

✍ Scribed by Yoko Tanaka, Bernard Halloran, Heinrich K. Schnoes and Hector F. DeLuca

Book ID
123656083
Publisher
National Academy of Sciences
Year
1979
Tongue
English
Weight
503 KB
Volume
76
Category
Article
ISSN
0027-8424

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Cultured microglial cells were examined for their ability to metabolize 25-hydroxyvitamin D, (25-(OH) D,). Upon exposure to lipopolysaccharide, microglial cells produced a vitamin D metabolite which comigrated with synthetic 1,25-dihydroxyvitamin D, (1,25-(OH),D,) in two different systems of high pe