✦ LIBER ✦

In vitro photosensitized lysis of red blood cells by an antifungal drug griseofulvin

✍ Scribed by Hitoshi Fujita; Noriko Inukai; Itsuro Matsuo

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 392 KB
Volume: 17
Category: Article
ISSN: 1011-1344
DOI: 10.1016/1011-1344(93)85010-6

No coin nor oath required. For personal study only.

✦ Synopsis

Human red blood cells (RBCs) were lysed by in vitro irradiation in the presence of the antifungal drug griseofulvin (GF). Effects of UVA fluence and GF concentration on photohaemolysis were examined under aerobic conditions. The photohaemolysis occurred at much lower fluence than that necessary for oxidation of the membrane lipids. UVA-irradiated solution of GF did not cause haemolysis. The photohaemolysis was colloid osmotic in nature because it was preceded by K+ leakage from the cells and was delayed in the presence of 30 mM sucrose in the medium. Even under anaerobic conditions, RBCs were lysed by irradiation with higher fluence than that required for aerobic photohaemolysis. Therefore, some phototoxic mechanism other than photosensitized oxidation is also involved in the photohaemolysis.

📜 SIMILAR VOLUMES

Plasminogen activation and lysis of bloo

Plasminogen activation and lysis of blood clots induced by cells in vitro

✍ Peter Knox; Sheila Crooks 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 770 KB

When human diploid fibroblasts were seeded onto the surface of blood clots, lysis of the clot occurred as a result of the release of cellular plasminogen activator. A

Rapid biotransformation of satraplatin b

Rapid biotransformation of satraplatin by human red blood cells in vitro

✍ Jocelyn L. Carr; Malcolm D. Tingle; Mark J. McKeage 📂 Article 📅 2002 🏛 Springer 🌐 English ⚖ 136 KB

In vitro oxime reactivation of red blood

In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon

✍ G. A. Petroianu; K. Arafat; S. M. Nurulain; K. Kuča; J. Kassa 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 623 KB

In vitro oxime protection of human red b

In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate

✍ D. E. Lorke; M. Y. Hasan; K. Arafat; K. Kuča; K. Musilek; A. Schmitt; G. A. Petr 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 350 KB

Oximes are enzyme reactivators used in treating poisoning with organophosphorus cholinesterase (AChE) inhibitors. The oxime dose which can be safely administered is limited by the intrinsic toxicity of the substances such as their own AChE-inhibiting tendency. Clinical experience with the available

Fast uptake kinetics in vitro of51Cr (VI

Fast uptake kinetics in vitro of51Cr (VI) by red blood cells of man and rat

✍ H. J. Wiegand; H. Ottenwälder; H. M. Bolt 📂 Article 📅 1985 🏛 Springer-Verlag 🌐 English ⚖ 331 KB

Fast transport kinetics of 51Cr (VI) into red blood cells (RBCs) in vitro were studied. No significant species differences were found between RBCs of man and rat. The uptake of 51Cr (VI) by RBCs in whole blood was composed of two different first order processes of different velocities (apparent t 1/

In vitro protection of red blood cell ac

In vitro protection of red blood cell acetylcholinesterase by metoclopramide from inhibition by organophosphates (paraoxon and mipafox)

✍ Georg Petroianu; Kholoud Arafat; Melita Kosanovic; Ayman Saleh; Vijayasarathy Ca 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB

Metoclopramide (MCP) is a dopamine receptor antagonist and serotonin receptor agonist widely used as an antiemetic and gastric prokinetic drug. In addition, MCP is a reversible inhibitor of cholinesterases from the human central nervous system and blood, and may have a red blood cell (RBC) acetylcho