In vitro phosphorylation of the acetylcholine receptor
β Scribed by TEICHBERG, VIVIAN ITZHAK; SOBEL, ANDRE; CHANGEUX, JEAN-PIERRE
- Book ID
- 109705101
- Publisher
- Nature Publishing Group
- Year
- 1977
- Tongue
- English
- Weight
- 608 KB
- Volume
- 267
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/267540a0
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π SIMILAR VOLUMES
We have found that the acetylcholine receptor (AChR) of Torpedo californica is phosphorylated and dephosphorylated in situ by a membrane-bound protein kinase and phosphatase [1]. There is increasing evidence that other neurotransmitters [2], light [3-6], polypeptide hormones [7], and growth factors
## Abstract Acetylcholine receptor (AChR) stability in the postsynaptic membrane is affected by serine kinases. AChR are phosphorylated by protein kinase C (PKC) and PKA, and we have shown that activation of PKA and PKC have opposite effects on AChR stability and that this may play some role in the
## Abstract Purified postsynaptic membranes can be used as a model system to study the regulation of synaptic membrane proteins. These membranes contain protein kinase activity that phosphorylates the acetylcholine receptor (AChR). We find that diphenylhydantoin (DPH) interacts with these membranes