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In vitro pharmacology of SCH 58261, a new potent and selective A2a adenosine receptor antagonist

✍ Scribed by C. Zocchi; E. Ongini; A. Conti; S. Ferrara; A. Negretti; S. Dionisotti

Book ID
119180096
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
159 KB
Volume
31
Category
Article
ISSN
1043-6618

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The recent discovery of selective antagonists for the A 2A adenosine receptors has been of great help to further research in this field. One compound, SCH 58261, 5-amino-7-(Ξ²-phenylethyl)-2-(8furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine, is playing a key part in a variety of studies. This r

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The tritium labeled form of 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo[4,3-e] 1,2,4-triazolo[l,5-c]pyrimidine (3H-SCH 58261) was obtained by reduction of 5-amino-7-[2-(2',4',5'-tribromo)phenylethyl]-2-(2-furyl)-pyrazolo[4,3-e] 1,2,4-triazolo[ 1,5clpyrimidine with tritium gas in the presence of 10

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