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In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu®) and active metabolite

✍ Scribed by Lothar Lindemann; Helmut Jacobsen; Diana Schuhbauer; Frederic Knoflach; Silvia Gatti; Joseph G. Wettstein; Hansruedi Loetscher; Tom Chu; Martin Ebeling; James C. Paulson; Eric Prinssen; Manfred Brockhaus

Book ID
113588553
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
249 KB
Volume
628
Category
Article
ISSN
0014-2999

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✍ A.A.E. Bertelli; C. Mannari; S. Santi; C. Filippi; M. Migliori; L. Giovannini 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB 👁 1 views

## Abstract The risk of an avian influenza pandemic has put oseltamivir (Tamiflu®) in the spotlight and has given rise to rumors that shikimic acid (SK), which is used for the synthesis of Tamiflu®, possesses therapeutic activity. This study was undertaken to determine whether SK, either alone or i