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In vitro pharmacodynamic evaluation of VP-16-213 and implications for chemotherapy

✍ Scribed by S. N. Wolff; W. W. Grosh; K. Prater; K. R. Hande

Publisher
Springer
Year
1987
Tongue
English
Weight
393 KB
Volume
19
Category
Article
ISSN
0344-5704

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Chemotherapy combination with cyclophosphamide (CTX) adriamycin (ADM), vincristine (VCR), and VP16-213 in small cell carcinoma of the lung (SCCL)
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Twenty-four evaluable patients with small cell carcinoma of the lung were treated with an escalating chemotherapy regimen including Cyclophosphamide, Adriamycin, Vincristine and VP16-213. The initial doses were CTX 800 mg/m2 i.v. day 1; ADR 50 mg/m2 i.v. day 1; VCR 1.4 mg/m2 day 1 weekly; and VP16-2