๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

In vitro percutaneous permeation of betamethasone and betamethasone 17-valerate

โœ Scribed by Kiyoshi Kubota; Howard I. Maibach

Book ID
102918914
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
854 KB
Volume
82
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

โœฆ Synopsis

Models of drug delivery devices that employ erodible permeable coatings must take care to avoid the unacceptably high rate of release that arises as the erodible coating disappears and the barrier to drug release vanishes. One solution to this safety problem has been to exhaust the drug reservoir just before this condition occurs. This design has the disadvantage of placing demands of high accuracy on the quality control in the fabrication of the device. A drug delivery system of cylindrical symmetry is proposed that uses two permeable coatings on a drug-containing core. Only the outer of the two coatings is erodible; the inner safety coating and the core are inert. Calculations are performed to design the device that can yield constant drug delivery rates while avoiding the possibility of explosive late drug release.

๐Ÿ“œ SIMILAR VOLUMES

Percutaneous permeation of betamethasone
Percutaneous permeation of betamethasone 17-valerate incorporated in lipid nanoparticles
โœ Jin Zhang; Eric Smith ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB

Corticosteroids are therapeutic agents widely used in the pharmacological treatment of skin diseases such as eczema or psoriasis. Unfortunately, their use is restricted by the side effects that frequently occur at the systemic level. The goal of the research described here was to develop and charact

Significance of viable skin layers in pe
Significance of viable skin layers in percutaneous permeation and its implication in mathematical models: Theoretical consideration based on parameters for betamethasone 17-valerate
โœ Kiyoshi Kubota; Howard I. Maibach ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 721 KB

The role of viable skin layers (viable epidermis and dermis) is examined by the three-layer model using parameter values for betamethasone 17-valerate. The mathematical three-layer diffusion model indicates that the lag time and half-life after vehicle removal in epidermis and split-thickness skin a