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In vitro NMR investigation of controlled single and repeated isoflurane anesthesia

✍ Scribed by P. Holzmüller; E. Moser; A. Werba; E.M. Markis; G. Gomiscek

Book ID
103909637
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
911 KB
Volume
10
Category
Article
ISSN
0730-725X

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✦ Synopsis

Immobilization of laboratory animals is a basic requirement for experimental in vivo NMR measurements. The effect of single and repeated isoflurane anesthesia on proton NMR relaxation times T1 and T2 in rat liver was studied. Furthermore, physiological monitoring was performed to evaluate the influence of isoflurane anesthesia (up to 2 hr) on biological parameters. Neither single nor repeated isoflurane application over the observed time produce relevant alterations of physiological parameters or relaxation times, compared with untreated control groups. Therefore, we conclude that isoflurane anesthesia is appropriate for in vivo NMR investigations, especially of the liver.

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