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In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives

โœ Scribed by Stephen T. Buckley; Sarah M. Fischer; Gert Fricker; Martin Brandl


Book ID
113592574
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
636 KB
Volume
45
Category
Article
ISSN
0928-0987

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โœ Philip J. Sassene; Matthias M. Knopp; Janne Z. Hesselkilde; Vishal Koradia; Anne ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 311 KB

Precipitation of cinnarizine during in vitro lipolysis of a self-microemulsifying drug delivery system (SMEDDS) was characterized to gain a better understanding of the mechanisms behind the precipitation. During in vitro lipolysis of the SMEDDS with or without cinnarizine, samples were taken at seve