Zafirlukast is a cysteinyl leukotriene antagonist used to treat allergic and exercise-induced asthma. This in vitro study used human liver microsomes to evaluate the inhibitory activity of zafirlukast versus six human cytochrome P450 (CYP) isoforms. Zafirlukast (0 -250 mM) was co-incubated with fixe
In vitro metabolism of tributyltin and triphenyltin by human cytochrome P-450 isoforms
โ Scribed by Shuji Ohhira; Mitsunori Enomoto; Hisao Matsui
- Book ID
- 108287362
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 300 KB
- Volume
- 228
- Category
- Article
- ISSN
- 0300-483X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The two CHCl3 activation pathways have been studied in incubations at different oxygenation conditions with hepatic microsomes from control Sprague Dawley (SD) rats or SD rats treated with different cytochrome P450 inducers (acetone, phenobarbital, pyrazole, dexamethasone, and beta-naphthoflavone).
The metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and assayed for mirtazapine enantiomers using a validated chiral method of high-performance liquid chroma
## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th