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In vitro metabolism of teratogens by differentiating rat embryo cells

โœ Scribed by Brown, L.P.; Flint, O.P.; Orton, T.C.; Gibson, G.G.

Book ID
121350458
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
524 KB
Volume
24
Category
Article
ISSN
0278-6915

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An in vivo-in vitro test system with high sensitivity to teratogens has been developed and validated. A single acute intra-peritoneal injection of teratogens (1 8) and non-teratogens (13) was administered to pregnant rats on the 12th day after fertilisation, and uteri were removed after 16 h by lapa