In vitro metabolism of N-nitrosopyrrolidine by rat lung subcellular fractions: α-hydroxylation in a non-target tissue

A multiplicity of protein antigens in su

A multiplicity of protein antigens in subcellular fractions of rat insulinoma tissue are able to stimulate T cells obtained from non-obese diabetic mice

✍ S. Bieg; E. M. Bailyes; N. Yassin; J. Amann; L. Herberg; A. M. McGregor; W. A. S 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 776 KB

Type 1 (insulin-dependent) diabetes mellitus is a T-cell mediated autoimmune disease with a number of different proteins being implicated as target autoantigens. A 38 kDa protein residing in the insulin secretory granule of insulinoma tissue is recognized by T-cell clones from a newly-diagnosed Type