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In-vitro metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by liver and intestinal mucosa homogenates from the winter flounder (Pseudopleuronectes americanus)

✍ Scribed by Anne E. McElroy; Kevin M. Kleinow

Book ID: 119068381
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 328 KB
Volume: 34
Category: Article
ISSN: 0141-1136
DOI: 10.1016/0141-1136(92)90121-2

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino