## Abstract This study was undertaken to examine macrophage response to polycarbonateβurethane, a proposed alternative material to polyethylene in acetabular components of total hip arthroplasty. Polyethylene wear debris from total joint replacements has been linked to osteolysis and implant lifesp
In vitro macrophage response to polyethylene and polycarbonate-urethane particles
β Scribed by Richard A. Smith; Nadim James Hallab
- Book ID
- 118284155
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 339 KB
- Volume
- 9999A
- Category
- Article
- ISSN
- 1549-3296
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Several investigators have suggested that biologic molecules adsorbed onto particles may play a key role in determining macrophage response. Adsorbed endotoxins (bacterial debris) may be of particular importance since they are widely present exogenously and endogenously and adhere strongly to many m
Using the J774 macrophage cell line, we designed an in vitro model to analyze by flow cytometry the effects of size, concentration, and composition of ceramic (Al2O3 and ZrO2) and high density polyethylene (HDP) particles on phagocytosis and cell mortality. Inflammatory mediator (TNF-alpha) also was