In Vitro Localized Release of Thermosensitive Liposomes with Ultrasound-Induced Hyperthermia
β Scribed by Mannaris, Christophoros; Efthymiou, Eleni; Meyre, Marie-Edith; Averkiou, Michalakis A.
- Book ID
- 121889277
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 564 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0301-5629
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## Abstract ## Purpose To investigate the feasibility of local delivery of a magnetic resonance (MR) contrast agent in vivo using paramagnetic thermosensitive liposomes and infrared (IR) laserβinduced local hyperthermia under realβtime MR thermometry on rabbit kidney. ## Materials and Methods Re
We evaluated the characteristics of laser-induced release of an antimetabolite (cytosine arabinoside) from temperature-sensitive liposomes. Previous work had shown that a laser would induce breakdown of liposomes when a dye was encapsulated within the liposomes. The present investigation was perform