In vitro lifespan and senescence mechanisms of human nucleus pulposus chondrocytes
โ Scribed by Jeong, Seo-Won; Lee, Jun-Seok; Kim, Ki-Won
- Book ID
- 121423508
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 669 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1529-9430
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Collagen fibrils are the main structural components of the nucleus pulposus tissue in the intervertebral discs. The structureproperty relationship of the nucleus pulposus (NP) tissues is still unclear. We investigated the structure of individual collagen fibrils of the NP and evaluated its correlati
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Cell hybrids were formed between human diploid fibroblasts (HDF) and carcinogen-transformed H D F to determine the relationship among: (1) finite proliferative lifespan, which we define as an age-related failure of a population to achieve one population doubling in 4 weeks; (2) arrest in a senescent