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In vitro inhibition of OATP-mediated uptake of phalloidin using bile acid derivatives

✍ Scribed by Elisa Herraez; Rocio I.R. Macias; Jose Vazquez-Tato; Marta Vicens; Maria J. Monte; Jose J.G. Marin


Book ID
113924548
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
556 KB
Volume
239
Category
Article
ISSN
0041-008X

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Organic anion–transporting polypeptide 1
✍ IvΓ‘n L. Csanaky; Hong Lu; Youcai Zhang; Kenichiro Ogura; Supratim Choudhuri; Cur πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 713 KB

The organic anion-transporting polypeptide 1b family (Oatp1b2 in rodents and OATP1B1/1B3 in humans) is liver-specific and transports various chemicals into the liver. However, the role of the Oatp1b family in the hepatic uptake of bile acids (BAs) into the liver is unknown. Therefore, in Oatp1b2-nul