Inhibition of human cytochrome P450 isof
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Richard I. Shader; Brian W. Granda; Lisa L. von Moltke; Gina M. Giancarlo; David
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Article
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1999
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John Wiley and Sons
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English
β 135 KB
π 1 views
Zafirlukast is a cysteinyl leukotriene antagonist used to treat allergic and exercise-induced asthma. This in vitro study used human liver microsomes to evaluate the inhibitory activity of zafirlukast versus six human cytochrome P450 (CYP) isoforms. Zafirlukast (0 -250 mM) was co-incubated with fixe