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In vitro infection of CD4+ T lymphocytes with HTLV-I generates immortalized cell lines coexpressing lymphoid and myeloid cell markers

✍ Scribed by Tricarico, M; Macchi, B; D’Atri, S; Morrone, S; Bonmassar, E; Fuggetta, M P; Graziani, G

Book ID: 110054096
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 246 KB
Volume: 13
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2401296

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Lymph nodes from the incipient or early neoplastic phase of adult T-cell leukemia/lymphoma (ATLL) histologically resemble Hodgkin's disease. Integrated proviral human Tlymphotrophic virus type I (HTLV-I) has been demonstrated in such lesions. We studied 18 patients with this disease, and about half