Four experimental controlled-release oral solid dosage formulations were developed and the in vitro dissolution characteristics of theophylline from these formulations were studied in USP apparatus I. Pharmacokinetic evaluation of these formulations was carried out in eight beagle dogs under fasting
In vitro-in vivo correlation for modified-release formulations
โ Scribed by Jorgen Drewe; Patrice Guitard
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 656 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0022-3549
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## Abstract An __in vitro__โ__in vivo__ correlation (IVIVC) was established for an osmotic controlledโrelease dosage form by deconvolution using data from an immediateโrelease treatment as the characteristic response. The established IVIVC was evaluated internally (predicting data used to develop t
Development of a controlled-released formulation of chlorpheniramine maleate is described, using in vitro/in vivo correlates, according to a process that has been termed "biorelevant dissolution". The process begins with simulations using several possible input rates combined with known disposition