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In vitro immunological studies on east african cancer patients. III. Spontaneous rosette formation by cells from burkitt lymphoma biopsies

✍ Scribed by R. L. Gross; C. M. Steel; A. G. Levin; S. Singh; G. Brubaker

Publisher: John Wiley and Sons
Year: 1975
Tongue: French
Weight: 402 KB
Volume: 15
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910150116

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✦ Synopsis

Abstract

Spontaneous rosette formation was observed in eight out of nine Burkitt lymphoma biopsies. These were examined fresh and/or after culture in vitro for up to 48 h. The percentage of rosettes varied from 3.7% to 38%. There was a tendency for the percentage of rosettes to increase with time in tissue culture. It is suggested that the rosette‐forming cells are T‐lymphocytes infiltrating the tumour and functioning as a host defence mechanism against the proliferating tumour cells.

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In vitro immunological studies on east african cancer patients. II. Increased sensitivity of blood lymphocytes from untreated burkitt lymphoma patients to inhibition of spontaneous rosette formation

✍ R. L. Gross; A. G. Levin; C. M. Steel; S. Singh; G. Brubaker; F. G. Peers 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 483 KB

## Abstract Frozen aliquots of peripheral blood mononuclear cells from patients with Burkitt's lymphoma (BL) at various stages of the disease have been compared with samples from East African children who were healthy or who suffered from non‐malignant disorders. Using the sheep‐cell rosette test (