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In vitro immune response of primed mouse spleen cells as affected by the time of antigenic stimulation

✍ Scribed by H. K. Meiss; G. Agarossi; M. Martinozzi; G. Doria

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
314 KB
Volume
76
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Normal and primed spleen cells stimulated in vitro with sheep RBC showed a different behaviour in the 19 S PFC response. The immunologic capacity of primed cells, unlike that of unprimed cells, was impaired if the antigen addition to culture had been delayed for more than six hours. The requirement of primed cells for immediate reexposure to antigen varied with the time of preimmunization and was maximum when spleen cells had acquired in the donor the ability to display the highest response in vitro upon optimal restimulation. This phenomenon of antigen requirement of primed cells in vitro is at variance with the known immunologic behaviour of primed cells grown in vivo, and can be attributed to cellular changes unmasked by in vitro cultivation.

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