IN VITRO GROWTH OF BASOPHILS CONTAINING THE PHILADELPHIA CHROMOSOME IN THE ACUTE PHASE OF CHRONIC MYELOGENOUS LEUKAEMIA
β Scribed by J. F. Denegri; S. C. Naiman; J. Gillen; J. W. Thomas
- Book ID
- 114708870
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 263 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0007-1048
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## Abstract ## BACKGROUND Chronic myelogenous leukemia (CML) is characterized by a molecular aberration, a fusion __BCRβABL__ gene encoding for aberrant tyrosine kinase activity, which is crucial in the pathogenesis of CML. In vitro, inhibition of BCRβABL protein tyrosine kinase activity by a tyro